action error Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide. | Alzheimer Mullan Research Notes

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Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide.

A study entitled “Potent anti-angiogenic motifs within the Alzheimer’s β-amyloid peptide” was published in the January 2008 issue of the journal Amyloid. Building on previous work showing that the Alzheimer’s Aβ peptide is able to prevent blood vessel growth and inhibit tumor growth, Roskamp Institute scientists investigated particular sequences within the Alzheimer’s Aβ peptide in order to identify whether short derivatives of Aβ are able to have the same effect. Inhibition of blood vessel growth is an attractive approach for preventing tumorigenesis since tumors need an adequate blood supply to grow beyond a certain size. Using different fragments of the Aβ peptide, we have identified, for the first time, a critical 8 amino acid sequence within the Aβ peptide, HHQKLVFF, which is able to block blood vessel growth. This short peptide has potential therapeutic relevance for the prevention of tumor growth. The Roskamp Institute specializes in Alzheimer’s Disease research and under the leadership of Dr Michael Mullan has focussed on the role of inflammation in Alzheimer’s Disease and on new treatments for Alzheimer’s Disease and other disorders. This work was a spin off of Mullan and colleagues’ Alzheimer research which has previously shown that the Alzheimer’s Disease peptide can adversely impact blood vessels in Alzheimer’s Disease and may contribute to the decline seen, for instance, after stroke in Alzheimer’s Disease patients.

For more details read the journal article at:
Patel NS, Quadros A, Brem S, Wotoczek-Obadia M, Mathura VS, Laporte V, Mullan M, Paris D. Amyloid. 2008 Mar;15(1):5-19.

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